Molecular Therapy — Nucleic Acids · 2020 · 42 citations · 33 references
MedicineMolecular BiologyOncologyGene ExpressionMolecular OncologyTumor ProgressionCancer GenomicsCancer ProgressionCancer TranscriptomicsColorectal CancerNoncoding Rna In CancerTumor Suppressor GenesCancer Cell Proliferation InhibitionCancer-related Noncoding Rna FunctionCyclin-dependent Kinase RegulationLong Noncoding Rna Regulation
phase. In tumorigenicity assays, STEAP3-AS1 knockdown could strongly inhibit tumor growth. Mechanistic investigations demonstrated that STEAP3-AS1 downregulation could increase the expression of cyclin-dependent kinase inhibitor 1C (CDKN1C) by STEAP3 upregulation. Overall, we identify the underlying role of MT1M-related lncRNA STEAP3-AS1 in colon cancer progression, which provides a novel strategy for colon cancer therapy.
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