Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

Jonathan E. Rosenberg, Jean Hoffman‐Censits, Tom Powles et al. · The Lancet · 2016 · 3.7K citations

Medicine, Oncology, Pharmacotherapy +13

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Haidong Dong, Gefeng Zhu, Koji Tamada et al. · Nature Medicine · 1999 · 2.5K citations

Life Sciences, Cell Biology, Immunology +10

Expanding the Genetic Code of <i>Escherichia coli</i>

Lei Wang, Ansgar Brock, Brad Herberich et al. · Science · 2001 · 1.5K citations

Life Sciences, Genetics, Molecular Biology +17

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

Jiajia Dong, Larissa B. Krasnova, M. G. Finn et al. · Angewandte Chemie International Edition · 2014 · 1.4K citations

Natural Sciences, Chemistry, Green Chemistry +7

Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

Howard L. Kaufman, Jeffery S. Russell, Omid Hamid et al. · The Lancet Oncology · 2016 · 1.2K citations · Full text

Medicine, Oncology, Pharmacology +11