Concepedia

Total synthesis of crotophorbolone

Tianzi Yu, Ying Sun, Canhui Tu, Ting Chen, Shaomin Fu, Bo Liu

Chemical Science · 2020 · 38 citations · 58 references

DOIFull text

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Concepts

Abstract

Convergent total synthesis of crotophorbolone was accomplished in 18 longest linear steps. Observation of unexpected thermodynamic stability of a <italic>cis,trans</italic>-5/7/6 tricycle would benefit synthetic design of tigliane- and daphnane-related diterpenoids.

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