Concepedia

High-capacity poly(2-oxazoline) formulation of TLR 7/8 agonist extends survival in a chemo-insensitive, metastatic model of lung adenocarcinoma

Natasha Vinod, Duhyeong Hwang, Salma H. Azam, Amanda E.D. Van Swearingen, Elizabeth Wayne, Sloane Christian Fussell, Marina Sokolsky‐Papkov, Chad V. Pecot, Alexander V. Kabanov

Science Advances · 2020 · 64 citations · 36 references

DOIFull text

Open access

Concepts

Abstract

immune response. Our study demonstrates the promise of poly(2-oxazoline)-formulated Resiquimod for treating metastatic NSCLC.

References

36

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Ting‐Chao Chou · Cancer Research · 2010 · 5.7K citations

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CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

Edith M. Janssen, Edward E. Lemmens, Tom Wolfe et al. · Nature · 2003 · 1.6K citations

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Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

Margherita Norelli, Barbara Camisa, Giulia Barbiera et al. · Nature Medicine · 2018 · 1.4K citations

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Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases

Jiyeon Yang, Lixiao Zhang, Caijia Yu et al. · Biomarker Research · 2014 · 1.1K citations · Full text

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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

Christopher B. Rodell, Sean P. Arlauckas, Michael F. Cuccarese et al. · Nature Biomedical Engineering · 2018 · 1.1K citations

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