Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities

Taylor Morrisette, Katherine L. Lev, Razieh Kebriaei, Jacinda C. Abdul‐Mutakabbir, Kyle Stamper, Sandra Morales, Susan M. Lehman, Gregory S. Canfield, Breck A. Duerkop, César A. Arias,

Antimicrobial Agents and Chemotherapy · 2020 · 38 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium . After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments.

References

25