A cost-effective detection of low-abundance mutation with DNA three-way junction structure and lambda exonuclease

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

Aaron M. Newman, Scott V. Bratman, Jacqueline To et al. · Nature Medicine · 2014 · 2.2K citations · Full text

Tumor Biology, Oncology, Engineering +14

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

Tim Forshew, Muhammed Murtaza, Christine Parkinson et al. · Science Translational Medicine · 2012 · 1.3K citations

Optimizing the specificity of nucleic acid hybridization

David Y. Zhang, Sherry Xi Chen, Peng Yin · Nature Chemistry · 2012 · 410 citations

Nucleic Acid Chemistry, Hybridisation, Hybridization +10

Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing

Jin Li, Lilin Wang, Harvey J. Mamon et al. · Nature Medicine · 2008 · 371 citations

Genetic Analysis, Dna Sequencing, Genetic Testing +10

Functional precision cancer medicine—moving beyond pure genomics

Anthony Letai · Nature Medicine · 2017 · 353 citations

Tumor Heterogeneity, Medicine, Cancer Cell Biology +8