Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

Sarah‐Jane Dawson, Dana W.Y. Tsui, Muhammed Murtaza, +15

New England Journal of Medicine

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

Muhammed Murtaza, Sarah‐Jane Dawson, Dana W.Y. Tsui, +14

Nature

Plasma DnaSomatic VariantAcquired ResistanceTumor HeterogeneityMedicine +10

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

Tim Forshew, Muhammed Murtaza, Christine Parkinson, +12

Science Translational Medicine

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Tomer Cooks, Ioannis S. Pateras, Lisa M. Jenkins, +7

Nature Communications

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

Tomer Cooks, Ioannis S. Pateras, Ohad Tarcic, +13

Cancer Cell

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

Jamie Weaver, Caryn S. Ross-Innes, Nicholas B. Shannon, +25

Nature Genetics

Esophageal CarcinogenesisSomatic VariantEsophageal CancerEsophagusMedicine +5

Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome

Paul Gissen, Colin A. Johnson, Neil V. Morgan, +20

Nature Genetics

Arthrogryposis–renal Dysfunction–cholestasisRenal PathologyPathologySnare-dependent Membrane FusionMembrane Biology +4

Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas

Tim Forshew, Ruth Tatevossian, Andrew Lawson, +14

The Journal of Pathology

Kiaa1549-braf Fusion VariantsNeuro-oncologyGliomaTumor HeterogeneityMedicine +13

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells

Maria Vinci, Anna Burford, Valeria Molinari, +32

Nature Medicine

Neuro-oncologyPediatric Brain TumorsSubclonal PopulationsGliomaTumor Heterogeneity +10

Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA

Davina Gale, Andrew Lawson, Karen Howarth, +23

PLoS ONE