Concepedia

The structure-based optimization of δ-sultone-fused pyrazoles as selective BuChE inhibitors

Ziwen Zhang, Jingli Min, Mengdie Chen, Xia Jiang, Yingying Xu, Hua‐Li Qin, Wenjian Tang

European Journal of Medicinal Chemistry · 2020 · 29 citations · 34 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryLead OptimizationStructure-activity RelationshipsEnzyme InhibitionLead Compound DesignLigand-based DesignMolecular DockingStereochemical OptimizationStructure-activity Relationship AnalysisPyrazole ChemistryStructure - Activity Relationship OptimizationStructure-activity Relationship Guided DesignStructure-based Lead DiscoveryStructure-based Ligand DesignStructure-based Selectivity Design

References

34

2016 Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2016 · 5.1K citations

Medicine, Geriatric Medicine, Population Health Sciences +17

2013 Alzheimer's disease facts and figures

William Thies, Laura Bleiler · Alzheimer s & Dementia · 2013 · 3.3K citations

Medicine, Geriatric Medicine, Neurology +17

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

Jiajia Dong, Larissa B. Krasnova, M. G. Finn et al. · Angewandte Chemie International Edition · 2014 · 1.4K citations

Natural Sciences, Chemistry, Green Chemistry +7

2017 Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2017 · 1.3K citations

Medicine, Geriatric Medicine, Dementia +16

Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

Yvain Nicolet, Oksana Lockridge, Patrick Masson et al. · Journal of Biological Chemistry · 2003 · 830 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16