Genetics · 2020 · 39 citations · 67 references
Life SciencesBiologyPhysiologyGene ExpressionInnate ImmunityTranscriptional RegulationCellular Responses To HypoxiaHypoxia AdaptationHypoxia PhysiologyImmune Gene RegulationImmune RegulationStress-responsive Gene RegulationForkhead Box O SignalingFoxo Transcriptional RegulationHypoxiaHypoxia ResponsesHypoxia Tolerance MechanismsInnate Immune ControlInnate Immunity PathwaysSurvival Under Hypoxia
mutant animals show reduced survival in hypoxia. Together, these data indicate that FOXO is a hypoxia-inducible factor that mediates tolerance to low oxygen by inducing immune-like responses.
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HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
Thorsten Cramer, Yuji Yamanishi, Björn E. Clausen et al. · Cell · 2003 · 2K citations · Full text
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Jordi Rius, Mónica Gumá, Christian Schachtrup et al. · Nature · 2008 · 1.6K citations · Full text
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
Dae‐Sung Hwangbo, Boris Gersham, Meng‐Ping Tu et al. · Nature · 2004 · 975 citations
Life Sciences, Biology, Genetics +14
Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival
Ernestina Schipani, Heather E. Ryan, Susanna Didrickson et al. · Genes & Development · 2001 · 792 citations · Full text
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