Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

A C. elegans mutant that lives twice as long as wild type

Cynthia Kenyon, Jean Chang, Erin Gensch et al. · Nature · 1993 · 3.4K citations

Life Sciences, Biology, Genetics +6

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann et al. · Nature · 2003 · 2.3K citations

Education, Genetics, Molecular Genetics +11

A Mutant <i>Drosophila</i> Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Marc Tatar, A. H. Kopelman, Diane Epstein et al. · Science · 2001 · 1.6K citations

Life Sciences, Biology, Genetics +17

Extension of Life-Span by Loss of CHICO, a <i>Drosophila</i> Insulin Receptor Substrate Protein

David J. Clancy, David Gems, Lawrence G. Harshman et al. · Science · 2001 · 1.4K citations

Education, Biology, Genetics +17

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

Matthias Blüher, Barbara B. Kahn, C. Ronald Kahn · Science · 2003 · 1.4K citations

Education, Endocrinology, Physiology +17