Concepedia

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers

Nathan Damaschke, Joseph Gawdzik, Mele Avilla, Bing Yang, John Svaren, Avtar Roopra, Jianhua Luo, Yan Yu, Sündüz Keleş, David F. Jarrard

Clinical Epigenetics · 2020 · 51 citations · 45 references

DOIFull text

Open access

Abstract

These findings establish CTCF loss as a major mediator in directing localized DNA hypermethylation events in a tissue-specific fashion and further support its role as a driver of the cancer phenotype.

References

45

NIH Image to ImageJ: 25 years of image analysis

Caroline A Schneider, Wayne Rasband, Kevin W. Eliceiri · Nature Methods · 2012 · 62.8K citations · Full text

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Sven Heinz, Christopher Benner, Nathanael J. Spann et al. · Molecular Cell · 2010 · 14K citations · Full text

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The Molecular Taxonomy of Primary Prostate Cancer

Adam Abeshouse, Jaeil Ahn, Rehan Akbani et al. · Cell · 2015 · 3.1K citations · Full text

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The mutational landscape of lethal castration-resistant prostate cancer

Catherine S. Grasso, Yi-Mi Wu, Dan R. Robinson et al. · Nature · 2012 · 2.6K citations

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Insulator dysfunction and oncogene activation in IDH mutant gliomas

William Flavahan, Yotam Drier, Brian B. Liau et al. · Nature · 2015 · 1.3K citations · Full text

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