Antimicrobial Agents and Chemotherapy · 2000 · 232 citations · 14 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceGenomicsMicrobial GeneticsAntibacterial ResistanceAntibiotic ResistanceAntibiotic Resistance GeneticsBeta-lactam ResistanceCarbapenem ResistanceResistance GenesAcinetobacter Baumannii ResistanceActive Site AnalysisActive Site CharacterizationBeta-lactamase GenesBeta-lactamase Mediated ResistanceFunctional MotifsPoint Mutation AnalysisProtein Amino Acid Pattern
The sequence of the bla(ARI-1) gene from imipenem-resistant Acinetobacter baumannii 6B92 has been determined. The structural gene encodes a 273-amino-acid protein which is most related to the OXA class D beta-lactamases. The conserved S-T-F-K and K-T-G motifs were identified in the ARI-1 protein sequence, also named OXA-23, but significantly, a point mutation (Y-->F) was identified in the Y-G-N conserved motif, also known to function in the active site.
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Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text
Photonic detection of bacterial pathogens in living hosts
Chritopher H. Contag, Pamela R. Contag, James I. Mullins et al. · Molecular Microbiology · 1995 · 657 citations