Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer

Abstract

Our findings showed that <i>IL-6</i> upregulation is essential for both IBD and CRC development until the upregulation of other Th17/Treg related genes (<i>TGFb1, IL-10, IL-23</i>, and transcription factor <i>FoxP3</i>) is a crucial primarily for CRC development. The significantly upregulated <i>IL-6</i> could be a potential drug target for IBD and prevention of CRC development as well.