World Journal of Gastroenterology · 2020 · 56 citations · 23 references
MedicineImmunologyOncologyCarcinogenesisImmunoregulationInflammationColorectal CancerCytokine BiologyCytokine SignalingGastrointestinal InflammationInflammatory BiomarkersInflammatory Bowel DiseaseColonic InflammationInflammatory Bowel Disease Cytokine NetworksInflammatory Bowel Disease ImmunopathogenesisInflammatory Bowel Disease ImmunoregulationInflammatory Bowel Disease PathogenesisInflammatory Bowel Disease PathologyInflammatory Bowel Disease PathophysiologyTh17 Cell Differentiation
BACKGROUND: The connection between inflammatory bowel disease (IBD) and colorectal cancer (CRC) is well-established, as persistent intestinal inflammation plays a substantial role in both disorders. Cytokines may further influence the inflammation and the carcinogenesis process. AIM: To compare cytokine patterns of active IBD patients with early and advanced CRC. METHODS: Choosing a panel of cytokines crucial for Th17/Treg differentiation and behavior, in colon specimens, as mRNA biomarkers, and their serum protein levels. RESULTS: alone in advanced CRC. The protein levels of the cytokines were significantly higher in CRC patients compared to IBD patients. CONCLUSION: could be a potential drug target for IBD and prevention of CRC development as well.
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