Concepedia

PE_PGRS31-S100A9 Interaction Promotes Mycobacterial Survival in Macrophages Through the Regulation of NF-κB-TNF-α Signaling and Arachidonic Acid Metabolism

Sheng Liu, Yan Xie, Wei Luo, Yafeng Dou, Huan Xiong, Zhen Xiao, Xiao‐Lian Zhang

Frontiers in Microbiology · 2020 · 26 citations · 56 references

DOIFull text

Open access

Concepts

Abstract

Rv1768 promotes mycobacterial survival in macrophages by regulating NF-κB-TNF-α signaling and arachidonic acid metabolism via S100A9. Disturbing the interaction between Rv1768 and S100A9 may be a potential therapeutic target for tuberculosis.

References

56

Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray

Marcel A. Behr, Michael A. Wilson, Wendy Gill et al. · Science · 1999 · 1.5K citations

, , +15

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

Thomas Vogl, Klaus Tenbrock, Stephan Ludwig et al. · Nature Medicine · 2007 · 1.4K citations

, , +16

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

Eva Kaufmann, Joaquín Sanz, Jonathan L. Dunn et al. · Cell · 2018 · 1.2K citations · Full text

, , +11

Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis

Stoyan Bardarov, Svetoslav Bardarov, Martin S. Pavelka et al. · Microbiology · 2002 · 599 citations

, , +14

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

David M. Tobin, Francisco J. Roca, Sungwhan F. Oh et al. · Cell · 2012 · 572 citations · Full text

, , +16