Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

Chunfeng Li, Audrey Lee, Lilit Grigoryan, +21

Nature Immunology

VaccinationVaccine DevelopmentPathogenesisImmunologyPfizer-biontech Bnt162b2 Vaccine +6

B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

Wei Luo, Florian Weisel, Mark J. Shlomchik

Immunity

Synergistic InductionSignal TransductionSignaling PathwayAdaptive Immune SystemC-myc Transcription Factor +7

The B-cell surface protein CD72/Lyb-2 is the ligand for CDS

H. Van de Velde, Ilka von Hoegen, Wei Luo, +2

Nature

ImmunologyMolecular BiologyImmunologic MechanismAntigen ProcessingImmunotherapy +3

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Florian Weisel, Steven J. Mullett, Rebecca A. Elsner, +14

Nature Immunology

Energy MetabolismBiochemistryFatty AcidsBioenergeticsNatural Sciences +9

Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity

Gillie A. Roth, Emily C. Gale, Marcela Alcántara‐Hernández, +12

ACS Central Science

Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis

Meiling Su, Chaofei Chen, Shaoying Li, +21

Nature Cardiovascular Research

InflammationSevere SepsisBlood PlateletImmunologyCell Death +7

A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2

Qian Yin, Wei Luo, Vamsee Mallajosyula, +21

Nature Materials

IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells

Wei Luo, Laura Conter, Rebecca A. Elsner, +6

Science Immunology

SREBP signaling is essential for effective B cell responses

Wei Luo, Julia Z. Adamska, Chunfeng Li, +14

Nature Immunology

Signal TransductionSignaling PathwayCell RegulationSrebp SignalingMedicine +2

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells

Wei Luo, William F. Hawse, Laura Conter, +5

Nature Immunology

Signal TransductionSignaling PathwayCell RegulationProximal Bcr SignalingAkt Kinase +4