Concepedia

Structure‐based discovery of CZL80, a caspase‐1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility

Yangshun Tang, Bo Feng, Yi Wang, Huiyong Sun, Yi You, Jie Yu, Bin Chen, Cenglin Xu, Yeping Ruan, Sunliang Cui,

British Journal of Pharmacology · 2020 · 41 citations · 41 references

DOIFull text

Open access

Abstract

Caspase-1 is essential for FS generation. CZL80 is a promising low MW inhibitor of FS and later enhanced epileptogenic susceptibility.

References

41

Animal research: Reporting <i>in vivo</i> experiments: The ARRIVE guidelines

Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · British Journal of Pharmacology · 2010 · 3.6K citations · Full text

, , +18

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

Tingjun Hou, Junmei Wang, Youyong Li et al. · Journal of Chemical Information and Modeling · 2010 · 2.6K citations

Non-canonical inflammasome activation targets caspase-11

Nobuhiko Kayagaki, Søren Warming, Mohamed Lamkanfi et al. · Nature · 2011 · 2.4K citations

, , +6

Animal Research: Reporting <i>in vivo</i> Experiments—The ARRIVE Guidelines

Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · Journal of Cerebral Blood Flow & Metabolism · 2011 · 2K citations · Full text

, , +12

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

Simon D Harding, Joanna L Sharman, Elena Faccenda et al. · Nucleic Acids Research · 2017 · 1.6K citations · Full text

, , +17