Emerging Role of Mucolipins TRPML Channels in Cancer

A Landscape of Driver Mutations in Melanoma

Eran Hodis, Ian R. Watson, Gregory V. Kryukov et al. · Cell · 2012 · 2.6K citations · Full text

Somatic Variant, Driver Mutations, Medicine +5

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

Xian‐Ping Dong, Dongbiao Shen, Xiang Wang et al. · Nature Communications · 2010 · 627 citations · Full text

Protein Secretion, Signal Transduction, Molecular Physiology +13

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

Xian‐Ping Dong, Xiping Cheng, Eric Mills et al. · Nature · 2008 · 546 citations · Full text

Pathogenesis, Immunology, Pathology +2

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

Xiaoli Zhang, Xiping Cheng, Lu Yu et al. · Nature Communications · 2016 · 535 citations · Full text

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

Dongbiao Shen, Xiang Wang, Xinran Li et al. · Nature Communications · 2012 · 485 citations · Full text

Proteinlipid Interaction, Molecular Biology, Lipid Movement +16