PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

Xian‐Ping Dong, Dongbiao Shen, Xiang Wang, +8

Nature Communications

Protein SecretionSignal TransductionMolecular PhysiologyBiochemistryMembrane Trafficking +11

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

Xian‐Ping Dong, Xiping Cheng, Eric Mills, +4

Nature

PathogenesisImmunologyPathologyMedicineCell Signaling

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

Xiang Wang, Xiaoli Zhang, Xian‐Ping Dong, +11

Cell

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

Dongbiao Shen, Xiang Wang, Xinran Li, +8

Nature Communications

Proteinlipid InteractionMolecular BiologyLipid MovementCellular PhysiologyAutophagy +14

TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation

Xiping Cheng, Jie Jin, Lily Hu, +14

Cell

Skin DevelopmentSignal TransductionMolecular PhysiologyDevelopmental BiologyCutaneous Biology +10

Neuregulin-1 Enhances Depolarization-Induced GABA Release

Ran‐Sook Woo, Xiao-Ming Li, Yanmei Tao, +11

Neuron

Molecular NeuroscienceG Protein-coupled ReceptorMedicinePhysiologyMechanism Of Action +2

Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint–waddler mice

Haoxing Xu, Markus Delling, Linyu Li, +2

Proceedings of the National Academy of Sciences

Retrograde regulation of motoneuron differentiation by muscle β-catenin

Xiao Ming Li, Xian‐Ping Dong, Shi Wen Luo, +9

Nature Neuroscience

Synaptic PlasticityMolecular NeuroscienceMolecular PhysiologyPhysiologyRetrograde Regulation +4

Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion

Qi Cao, Xi Zhong, Yuanjie Zou, +3

The Journal of Cell Biology

Protein SecretionMolecular BiologyIntra-endolysosomal CaCalcium ReleaseCellular Physiology +18

Activating Mutations of the TRPML1 Channel Revealed by Proline-scanning Mutagenesis

Xian‐Ping Dong, Xiang Wang, Dongbiao Shen, +7

Journal of Biological Chemistry

Trpml1 ChannelMucolipin TrpMolecular BiologyMolecular GeneticsCellular Physiology +16