Biomolecules & Therapeutics · 2020 · 22 citations · 18 references
MedicineDermatologyPharmacologyImmunopathologyInflammationInnate ImmunityAnti-inflammatory PharmacologyInflammasome ActivationInflammatory PathologyInflammatory SignalingInflammatory Skin DiseasesRheumatoid ArthritisAnti-inflammatory MechanismsAnti-inflammatory RepurposingAnti-inflammatory TherapeuticsHost Defense ModulationInflammasome Inhibition MechanismsNlr Family Pyrin Domain-containing 3 InflammasomeNlrp3 InflammasomeRheumatoid Arthritis Therapy
in mouse ear skin. These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms. The results further suggest that topical application of auranofin could be a new therapeutic strategy for treating acne vulgaris by targeting the NLRP3 inflammasome.
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Inflammatory Events Are Involved in Acne Lesion Initiation
Anthony H.T. Jeremy, D.B. Holland, Susan G. Roberts et al. · Journal of Investigative Dermatology · 2003 · 549 citations
Medicine, Dermatology, Immunology +13
The use of isotretinoin in acne
Alison Layton · Dermato-Endocrinology · 2009 · 310 citations · Full text
Medicine, Dermatology, Pharmacology +12