Validation of distinct type 2 diabetes clusters and their association with diabetes complications in the <scp>DEVOTE</scp> , <scp>LEADER</scp> and <scp>SUSTAIN</scp> ‐6 cardiovascular outcomes trials

Abstract

Previously identified clusters can be replicated in three geographically diverse cohorts of long-standing T2D and are associated with cluster-specific risk profiles for additional clinical and survival outcomes, providing further validation of the clustering methodology. The external validity and stability of clusters across cohorts provides a premise for future work to optimize the clustering approach to yield T2D subgroups with maximum predictive validity who may benefit from subtype-specific treatment paradigms.