Concepedia

Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity

Neeharika Nemani, Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, R. Karthik, Benjamin T. Enslow, Cherubina S. Rubannelsonkumar, Santhanam Shanmughapriya, Varshini Mallireddigari, Soumya Maity,

Science Signaling · 2020 · 71 citations · 57 references

DOIFull text

Open access

Concepts

Abstract

Nutrient stress triggers transcriptional changes that limit Ca 2+ influx into mitochondria through the MCU.

References

57

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed · 1997 · 66.6K citations

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Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature · 2008 · 6.4K citations · Full text

, , +14

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

Martin D. Bootman, Ludwig Missiaen, Jan B. Parys et al. · Biochemical Journal · 1995 · 5.1K citations

, , +17

Methods in Mammalian Autophagy Research

Noboru Mizushima, Tamotsu Yoshimori, Beth Levine · Cell · 2010 · 4.5K citations · Full text

, , +10

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Daniel F. Egan, David B. Shackelford, Maria M. Mihaylova et al. · Science · 2010 · 2.6K citations

, , +17