Concepedia

Interleukin‐11 regulates the fate of adipose‐derived mesenchymal stem cells via STAT3 signalling pathways

Wenlong Yang, Shuning Zhang, Tiantong Ou, Hao Jiang, Daile Jia, Zhiyong Qi, Yunzeng Zou, Juying Qian, Aijun Sun, Junbo Ge

Cell Proliferation · 2020 · 21 citations · 31 references

DOIFull text

Open access

Abstract

We provide the evidence that IL-11 promoted ADSCs proliferation, stimulated ADSCs migration and attenuated ADSCs apoptosis by activation of STAT3 signalling. These results suggest that IL-11 facilitated ADSCs engraftment in ischaemic tissue, thereby enhanced ADSCs therapeutic efficacy.

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