medRxiv · 2020 · 111 citations · 25 references
Veterinary MedicineInfectious Disease ControlInfectious DiseasesEmerging Infectious DiseasesInfection PreventionInfectious Disease EpidemiologyDisease ControlInfectious Disease DynamicsOutbreak ControlPandemic ResponsePathogen Transmission CyclesTransmission DynamicsCyclic BehaviorDisease Transmission DisruptionExposure Time ReductionHost InfectiousnessInfectious Disease EconomicsOrganizational ExitPhysical DistancingReproduction Number Analysis
Many countries have applied lockdown that helped suppress COVID-19, but with devastating economic consequences. Here we propose exit strategies from lockdown that provide sustainable, albeit reduced, economic activity. We use mathematical models to show that a cyclic schedule of 4-day work and 10-day lockdown, or similar variants, can prevent resurgence of the epidemic while providing part-time employment. The cycle pushes the reproduction number R below one by reduced exposure time and by exploiting the virus latent period: those infected during work days reach peak infectiousness during lockdown days. The number of work days can be adapted in response to observations. Throughout, full epidemiological measures need to continue including hygiene, physical distancing, compartmentalization, testing and contact tracing. This conceptual framework, when combined with other interventions to control the epidemic, can offer the beginnings of predictability to many economic sectors.
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Temporal dynamics in viral shedding and transmissibility of COVID-19
Xi He, Eric H. Y. Lau, Peng Wu et al. · Nature Medicine · 2020 · 4.7K citations · Full text
Veterinary Medicine, Infectious Disease Control, Infectious Diseases +17
Neil M. Ferguson, Daniel J. Laydon, G Nedjati Gilani et al. · Spiral (Imperial College London) · 2020 · 3.8K citations · Full text
Medicine, Infectious Disease Control, Infectious Diseases +13