Concepedia

Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System

Mark Petchey, Benjamin Rowlinson, Richard C. Lloyd, Ian J. S. Fairlamb, Gideon Grogan

ACS Catalysis · 2020 · 80 citations · 21 references

DOIFull text

Open access

Concepts

Abstract

PPK in the presence of polyphosphoric acid and 0.1 equiv of ATP, required for recycling of the cofactor.

References

21

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Oleg Trott, Arthur J. Olson · Journal of Computational Chemistry · 2009 · 37.1K citations · Full text

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Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

Dean G. Brown, Jonas Boström · Journal of Medicinal Chemistry · 2015 · 2K citations · Full text

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Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase

Albert S. Reger, Rui Wu, Debra Dunaway‐Mariano et al. · Biochemistry · 2008 · 134 citations · Full text

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Enzyme‐Catalysed Synthesis of Secondary and Tertiary Amides

Mark Petchey, Gideon Grogan · Advanced Synthesis & Catalysis · 2019 · 118 citations

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Discovery of McbB, an Enzyme Catalyzing the β‐Carboline Skeleton Construction in the Marinacarboline Biosynthetic Pathway

Qi Chen, Changtao Ji, Yongxiang Song et al. · Angewandte Chemie International Edition · 2013 · 107 citations

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