Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases

DADA2: High-resolution sample inference from Illumina amplicon data

Benjamin J. Callahan, Paul J. McMurdie, Michael Rosen et al. · Nature Methods · 2016 · 36.3K citations

Life Sciences, Bioinformatics, Genetics +9

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

Christian Quast, Elmar Pruesse, Pelin Yilmaz et al. · Nucleic Acids Research · 2012 · 34K citations · Full text

Life Sciences, Bioinformatics, Microbiology +17

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 4K citations · Full text

Life Sciences, Immunology, Molecular Medicine +12

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

Sama I. Sayin, Annika Wahlström, Jenny Felin et al. · Cell Metabolism · 2013 · 2.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

Anne M. Evans, Corey D. DeHaven, Tom Barrett et al. · Analytical Chemistry · 2009 · 1.4K citations

Life Sciences, Biochemistry, Analytical Chemistry +16