Concepedia

QSAR modelling and molecular docking studies for anti-cancer compounds against melanoma cell line SK-MEL-2

Abdullahi Bello Umar, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba

Heliyon · 2020 · 40 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

) the known inhibitor of the target (V600E-BRAF). These findings may be very helpful in early anti-cancer drug development.

References

25

Computer Aided Design of Experiments

R. W. Kennard, L. A. Stone · Technometrics · 1969 · 3.4K citations

, , +11

PaDEL‐descriptor: An open source software to calculate molecular descriptors and fingerprints

Chun Wei Yap · Journal of Computational Chemistry · 2010 · 3K citations · Full text

, , +15

The Importance of Being Earnest: Validation is the Absolute Essential for Successful Application and Interpretation of QSPR Models

Alexander Tropsha, Paola Gramatica, Vijay K. Gombar · QSAR & Combinatorial Science · 2003 · 2.2K citations

, , +16

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

, , +14

BRAF and RAS mutations in human lung cancer and melanoma.

Marcia S. Brose, Patrícia Volpe, Michael D. Feldman et al. · PubMed · 2002 · 1K citations

, , +17