Bone‐protective effects of <i>Lactobacillus plantarum</i> B719‐fermented milk product

Abstract

The current study aimed to investigate the anti‐osteoporotic effects of a Lactobacillus plantarum B719‐fermented milk product (FMP‐B719). Higher proliferation and mineralisation were observed in FMP‐B719‐treated MC3T3‐E1 mouse pre‐osteoblastic cells than those in L. casei ATCC 393‐FMP‐treated MC3T3‐E1 cells. Moreover, FMP‐B719 normalised the serum alkaline phosphatase (9.37 ± 1.92 U/L) and phosphorus (8.28 ± 0.1 mg/dL) in a rat model of ovariectomy‐induced postmenopausal osteoporosis. Furthermore, FMP‐B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP‐B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.