ALCAM contributes to brain metastasis formation in non-small-cell lung cancer through interaction with the vascular endothelium

Abstract

1. ALCAM expression associates with poor prognosis and brain metastasis in NSCLC.2. ALCAM mediates interaction of NSCLC tumor cells with brain vascular endothelium.3. ALCAM might represent a novel preventive target to reduce the occurrence of BM in NSCLC.