Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Hania Kébir, Katharina Kreymborg, Igal Ifergan, +7

Nature Medicine

InflammationAutoimmune DiseaseBlood–brain BarrierMedicineImmunology +10

Single-cell analysis reveals T cell infiltration in old neurogenic niches

Ben W. Dulken, Matthew T. Buckley, Paloma Navarro Negredo, +12

Nature

Human CellMedicineT-regulatory CellSingle-cell BiologyNeural Stem Cell +8

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

Diana Matheoud, Tyler Cannon, Aurore N. Voisin, +13

Nature

Autoimmune DiseaseMucosal ImmunologyPathogenesisPink1−/− MiceGastroenterology +5

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

Romain Cayrol, Karolina Wosik, Jennifer L. Berard, +13

Nature Immunology

InflammationGranulocyteCell SignalingCell AdhesionMedicine +11

Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis

Karolina Wosik, Romain Cayrol, Aurore Dodelet-Devillers, +6

Journal of Neuroscience

Functional Consequences of Neuromyelitis Optica-IgG Astrocyte Interactions on Blood-Brain Barrier Permeability and Granulocyte Recruitment

Thierry Vincent, Philippe Saikali, Romain Cayrol, +4

The Journal of Immunology

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

Ilan Ifergan, Hania Kébir, Monique Bernard, +5

Brain

Statins reduce human blood–brain barrier permeability and restrict leukocyte migration: Relevance to multiple sclerosis

Igal Ifergan, Karolina Wosik, Romain Cayrol, +7

Annals of Neurology

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system

Catherine Larochelle, Romain Cayrol, Hania Kébir, +16

Brain

Lymphocyte DevelopmentImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +28

Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation

Ning Wu, Vitalij Černyšiov, Dominique Davidson, +14

Cell Reports

InflammationProteinlipid InteractionLipid Scramblase Tmem16fBiochemistryPlasma Membrane +8