Concepedia

Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia

Peleg Winer, Ivo S. Muskens, Kyle M. Walsh, Ajay Vora, Anthony V. Moorman, Joseph L. Wiemels, Irene Roberts, Anindita Roy, Adam J. de Smith

Blood Advances · 2020 · 10 citations · 23 references

DOIFull text

Open access

Concepts

Abstract

Key Points Rare and pathogenic germline variants, including in IKZF1, contribute to acute lymphoblastic leukemia in children with Down syndrome.

References

23

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Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia

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Ajay Vora, Nick Goulden, Rachel Wade et al. · The Lancet Oncology · 2013 · 483 citations · Full text

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