Haematologic malignancies associated with clozapine <i>v.</i> all other antipsychotic agents: a pharmacovigilance study in VigiBase^®

Abstract

Clozapine was significantly associated with a pharmacovigilance signal of haematologic malignancies. The risk-benefit balance of clozapine should be carefully assessed in patients with risk factors of haematologic malignancies. Clozapine should be used at the lowest effective posology.