Molecular Biology of the Cell · 2020 · 19 citations · 57 references
Life SciencesCell BiologyMolecular BiologyCell CycleMolecular Cell BiologyTranscriptional RegulationCell Cycle ControlCell Cycle TransitionsCell-cycle PhasesCell-cycle RegulationMitotic ExitS PhaseCell Cycle DynamicsCell-cycle OscillatorsE2f Transcriptional RepressionG0 Phase EntryProteolysis In Cell-cycle ControlProteolysis In G1StabilizationTranscriptional Repressor Complexes
We uncovered interlocking mechanisms regulating the temporal proteolysis of the transcriptional repressor E2F8 in cycling cells including SCF Cyclin F in G2, dephosphorylation of Cdk1 sites, and activation of APC/C Cdh1 , but not APC/C Cdc20 during mitotic exit and G1. Differential stabilization under limited APC/C activity allows E2F8 to reaccumulate during late G1 and coregulate S-phase entry.
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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
Andrea C. Carrano, Esther Eytan, Avram Hershko et al. · Nature Cell Biology · 1999 · 1.5K citations
Cyclin synthesis drives the early embryonic cell cycle
Andrew W. Murray, Marc W. Kirschner · Nature · 1989 · 1.2K citations