Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Shigeru Kotake, Nobuyuki Udagawa, Naoyuki Takahashi et al. · Journal of Clinical Investigation · 1999 · 1.7K citations · Full text

Medicine, Cell Biology, Immunology +17

Overexpression of toll‐like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll‐like receptor expression in early and longstanding arthritis

Caroline Ospelt, Fabia Brentano, Yvonne Rengel et al. · Arthritis & Rheumatism · 2008 · 348 citations

Life Sciences, Immunology, Pathobiology +13

Blocking of Interleukin-17 during Reactivation of Experimental Arthritis Prevents Joint Inflammation and Bone Erosion by Decreasing RANKL and Interleukin-1

Marije I. Koenders, Erik Lubberts, Birgitte Oppers‐Walgreen et al. · American Journal Of Pathology · 2005 · 308 citations · Full text

Veterinary Medicine, Immunology, Pathobiology +14

The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon

Sanna Rosengren, Maripat Corr, Gary S. Firestein et al. · Annals of the Rheumatic Diseases · 2011 · 164 citations

Medicine, Immunology, Molecular Biology +17

Combined Inhibition of Tumor Necrosis Factor α and Interleukin‐17 As a Therapeutic Opportunity in Rheumatoid Arthritis: Development and Characterization of a Novel Bispecific Antibody

Jens A. A. Fischer, Axel J. Hueber, Stacy Wilson et al. · Arthritis & Rheumatology · 2014 · 159 citations

Medicine, Immunology, Pathology +17