Concepedia

Metformin enhances the immunomodulatory potential of adipose-derived mesenchymal stem cells through STAT1 in an animal model of lupus

Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Seung‐Ki Kwok, Mi‐La Cho, Sung‐Hwan Park

Lara D. Veeken · 2019 · 66 citations · 33 references

DOI

Abstract

Metformin optimized the immunoregulatory properties of Ad-MSCs and may be a novel therapeutic agent for the treatment of lupus.

References

33

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.3K citations

Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue

Susanne Kern, Hermann Eichler, Johannes Stoeve et al. · Stem Cells · 2006 · 3.3K citations

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Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

Brian S. Andrews, Robert A. Eisenberg, Argyrios N. Theofilopoulos et al. · The Journal of Experimental Medicine · 1978 · 1.6K citations · Full text

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Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

José C. Crispín, Mohamed Oukka, George Bayliss et al. · The Journal of Immunology · 2008 · 780 citations · Full text

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Yongzhong Liu, Pin Zhang, Jun Li et al. · Nature Immunology · 2008 · 528 citations

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