Decreased secretion of tumor necrosis factor-α attenuates macrophages-induced insulin resistance in skeletal muscle

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.5K citations

Medicine, Endocrinology, Molecular Biology +17

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

K. Teoman Uysal, Sarah M. Wiesbrock, Michael W. Marino et al. · Nature · 1997 · 2.2K citations

Medicine, Endocrinology, Immunology +14

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

Philip A. Kern, Subramanian Ranganathan, Chunling Li et al. · American Journal of Physiology-Endocrinology and Metabolism · 2001 · 1.9K citations

Medicine, Endocrinology, Physiology +17

IKK-β links inflammation to obesity-induced insulin resistance

Melek C. Arkan, Andrea L. Hevener, Florian R. Greten et al. · Nature Medicine · 2005 · 1.8K citations

Life Sciences, Cell Biology, Physiology +14

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

Vincent Aguirre, Tohru Uchida, Lynne Yenush et al. · Journal of Biological Chemistry · 2000 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15