Concepedia

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

Kuan‐Wei Huang, Fu‐Fei Hsu, Guann-Jen Chern, Yi-An Lee, Chih‐Chun Chang, Yu‐Ting Huang, Yun‐Chieh Sung, Cheng-Chin Chiang, Rui-Lin Huang, Chu-Chi Lin,

Science Advances · 2020 · 254 citations · 17 references

DOIFull text

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Concepts

Abstract

T cells, augmented the efficacy of cancer vaccine immunotherapy, and suppressed HCC progression. Our work presents nanotechnology-enabled dual delivery of siRNA and plasmid DNA that selectively targets and reprograms the immunosuppressive tumor microenvironment to improve cancer immunotherapy.

References

17

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco, Haifa Shen, Mauro Ferrari · Nature Biotechnology · 2015 · 6.7K citations · Full text

, , +16

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

Shohei Koyama, Esra A. Akbay, Yvonne Y. Li et al. · Nature Communications · 2016 · 1.6K citations · Full text

, , +17

Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

Hélène Salmon, Juliana Idoyaga, Adeeb Rahman et al. · Immunity · 2016 · 1.2K citations · Full text

, , +16

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Elizabeth C. Carroll, Lei Jin, Andrés Mori et al. · Immunity · 2016 · 585 citations · Full text

, , +12

CXCR4 inhibition in tumor microenvironment facilitates anti‐programmed death receptor‐1 immunotherapy in sorafenib‐treated hepatocellular carcinoma in mice

Yunching Chen, Rakesh R. Ramjiawan, Thomas Reiberger et al. · Hepatology · 2014 · 458 citations · Full text

, , +17