Molecular and Cellular Biology · 2020 · 167 citations · 66 references
Life SciencesNeurobiologyNeuroscienceDementiaInflammationMolecular NeuroscienceAntioxidant DefenseInflammatory SignalingNeuroinflammationNeuroprotectionOxidative StressOxidative Stress MechanismsCellular Oxidative Stress ResponseNrf2-mediated Regulation Of GlutathioneOxidative BiomarkersOxidative Stress BiomarkersOxidative Stress InflammationOxidative Stress InjuryOxidative Stress-induced NeuroinflammationStress-responsive Transcription Factors
mice in the passive-avoidance task. These results demonstrate that the induction of Nrf2 ameliorates cognitive impairment in the AD model mouse by suppressing oxidative stress and neuroinflammation, suggesting that Nrf2 is an important therapeutic target of AD.
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