Concepedia

Buffered lidocaine 1%/epinephrine 1:100,000 with sodium bicarbonate (sodium hydrogen carbonate) in a 3:1 ratio is less painful than a 9:1 ratio: A double-blind, randomized, placebo-controlled, crossover trial

Alexandra Vent, Christian Surber, Nicole Tracy Graf Johansen, Verena Figueiredo, Georg Schönbächler, Laurence Imhof, Caroline Buset, Jürg Hafner

Journal of the American Academy of Dermatology · 2020 · 40 citations · 16 references

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Concepts

References

16

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

Bertil Hille · The Journal of General Physiology · 1977 · 1.8K citations · Full text

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Pain reduction in local anesthetic administration through pH buffering

Richard A. Christoph, Leslie Buchanan, Kimberly Begalla et al. · Annals of Emergency Medicine · 1988 · 332 citations

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The pH-dependent rate of action of local anesthetics on the node of Ranvier.

Bertil Hille · The Journal of General Physiology · 1977 · 268 citations · Full text

, , +17

Gating mechanisms of acid-sensing ion channels

Nate Yoder, Craig Yoshioka, Eric Gouaux · Nature · 2018 · 245 citations · Full text

, , +12

Decreasing the pain of local anesthesia: A prospective, double-blind comparison of buffered, premixed 1% lidocaine with epinephrine versus 1% lidocaine freshly mixed with epinephrine

Carrine A. Burns, Georgette Ferris, Changyong Feng et al. · Journal of the American Academy of Dermatology · 2005 · 89 citations

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