Molecular Therapy — Oncolytics · 2019 · 52 citations · 28 references
MedicineMolecular BiologyOncologyGene ExpressionMetastasisMolecular OncologyCancer ProgressionEpithelial-mesenchymal TransitionEpithelial-to-mesenchymal TransitionMicrorna BiologyNoncoding Rna In CancerOvarian CancerEpithelial-mesenchymal Transition In CancerEpithelial-mesenchymal Transition MarkersMicrorna DeregulationMicrorna In CancerMicrorna Regulation In CancerMicrorna Regulation Of EmtOvarian Cancer MetastasisOvarian Cancer Pathogenesis
. Meanwhile, knockdown of PTAL increased the expression of miR-101 and subsequently inhibited the expression of FN1. Importantly, PTAL positively regulated the expression of FN1 through sponging of miR-101 and promoted OvCa cell metastasis by regulating epithelial-mesenchymal transition. Overall, our study demonstrates the role of PTAL as a miRNA sponge in OvCa and suggests that PTAL may be a potential target for preventing OvCa metastasis.
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Predicting effective microRNA target sites in mammalian mRNAs
Vikram Agarwal, George W. Bell, Jin‐Wu Nam et al. · eLife · 2015 · 7.7K citations · Full text
Da Yang, Yan Sun, Limei Hu et al. · Cancer Cell · 2013 · 400 citations · Full text
Medicine, Cancer Biology, Oncology +17