Concepedia

A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development

Kate Lawrenson, Marcos A. Fonseca, Annie Y. Liu, Felipe Segato Dezem, Janet M. Lee, Xianzhi Lin, Rosario I. Corona, Forough Abbasi, Kevin C. Vavra, Huy Q. Dinh,

Cell Reports · 2019 · 62 citations · 62 references

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Concepts

Abstract

). The SOX18 transcription factor (TF) coincided with a HGSOC-specific SE, and ectopic overexpression of SOX18 in FTSECs caused epithelial-to-mesenchymal transition, indicating that SOX18 plays a role in establishing the mesenchymal signature of fallopian-derived HGSOCs.

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