Concepedia

Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions

Steffen Rickelt, Charlene Condon, Miyeko Mana, Christina Pfirschke, Jatin Roper, Deepa T. Patil, Ian Brown, Anthony R. Mattia, Lawrence Zukerberg, Qing Zhao,

Clinical Cancer Research · 2019 · 21 citations · 29 references

DOIFull text

Open access

Abstract

Muscularis mucosae-based AGRN immunostaining is a novel biomarker to distinguish SSL from HP, TSA, and TA, with a specificity of 97.1% and sensitivity of 98.9% and can assist in diagnosis of morphologically challenging colonic polyps.

References

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Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

Sayan Chakraborty, Kizito Njah, Ajaybabu V. Pobbati et al. · Cell Reports · 2017 · 212 citations · Full text

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