Organic Letters · 2019 · 45 citations · 12 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryStructure-activity RelationshipsSynthetic Medicinal ChemistryAnalgesiaAnalgesic PharmacologyAnti-inflammatory PharmacologyInflammation PharmacologyLead DiscoveryNatural Product Drug DiscoveryAnalgesic EffectsAnalgesic Natural ProductsAnti-inflammatory ActivityAnti-inflammatory Natural ProductsChemical Synthesis Of AnaloguesLead Discovery From Natural ProductsNatural Product Total SynthesisTotal Synthesis-derived Analogues
Dactylicapnosines A (1) and B (2), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in which dactylicapnosine A showed potent anti-inflammatory bioactivity in vitro. Inspired by its biosynthetic pathway, the total synthesis of dactylicapnosine A via 10 steps has been achieved and afforded enough material to prove its significant anti-inflammatory effect in vivo.
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Total synthesis of (−)-isatisine A via a biomimetic benzilic acid rearrangement
Mingxing Xiao, Wei Wu, Lin Wei et al. · Tetrahedron · 2014 · 34 citations