Preventive preclinical efficacy of intravenously administered sphingosine-1-phosphate (S1P) in strengthening hypoxia adaptive responses to acute and sub-chronic hypobaric hypoxia

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

Peichuan Zhang, Barbara C. McGrath, Sheng’ai Li et al. · Molecular and Cellular Biology · 2002 · 603 citations · Full text

Life Sciences, Molecular Biology, Physiology +17

Pulmonary Endothelial Cell Barrier Enhancement by Sphingosine 1-Phosphate

Steven M. Dudek, Jeffrey R. Jacobson, Eddie T. Chiang et al. · Journal of Biological Chemistry · 2004 · 300 citations · Full text

Life Sciences, Biochemistry, Physiology +13

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation

Victoria A. Blaho, Sylvain Galvani, Eric Engelbrecht et al. · Nature · 2015 · 231 citations

Life Sciences, Cell Biology, Neuroscience +12

Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

Kaiqi Sun, Yujin Zhang, Angelo D’Alessandro et al. · Nature Communications · 2016 · 212 citations · Full text

Life Sciences, Biochemistry, Physiology +17

Rat as a model for humanlike ventilatory adaptation to chronic hypoxia

E. B. Olson, Jerome A. Dempsey · Journal of Applied Physiology · 1978 · 170 citations

Life Sciences, Physiology, Animal Physiology +16