Concepedia

Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters

Zhongjian Wang, Hanyu Yang, Jiong Xu, Kaijing Zhao, Chen Yang, Limin Liang, Ping Li, Nan Chen, Donghao Geng, Xiangping Zhang,

Drug Metabolism and Disposition · 2019 · 32 citations · 41 references

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41

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Trudy Rodgers, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2006 · 940 citations

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Drug Absorption I: An In Situ Rat Gut Technique Yielding Realistic Absorption Rates

James T. Doluisio, Norman F. Billups, Lewis W. Dittert et al. · Journal of Pharmaceutical Sciences · 1969 · 349 citations

, , +12

Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells.

Rune Blomhoff, Magnhild Rasmussen, Å. Nilsson et al. · Journal of Biological Chemistry · 1985 · 210 citations · Full text

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Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study

Kazuya Maeda, Yasumasa Ikeda, Tomoe Fujita et al. · Clinical Pharmacology & Therapeutics · 2011 · 207 citations

, , +17

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

Takao Watanabe, Hiroyuki Kusuhara, Kazuya Maeda et al. · Drug Metabolism and Disposition · 2009 · 194 citations

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