Concepedia

Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling

Vijay Avin Balaji Ragunathrao, Mumtaz Anwar, Md Zahid Akhter, Alejandra Chavez, De Yu Mao, Viswanathan Natarajan, Sribalaji Lakshmikanthan, Magdalena Chrzanowska‐Wodnicka, Arkadiusz Z. Dudek, Lena Claesson‐Welsh,

Cell Reports · 2019 · 68 citations · 56 references

DOIFull text

Open access

Concepts

Abstract

mice. Our findings suggest that blocking S1PR1 activity in ECs has the potential to suppress tumor growth by preventing amplification of VEGF-VEGFR2 signaling.

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SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

T. Annie T. Fong, Laura K. Shawver, Li Sun et al. · PubMed · 1999 · 1K citations

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