Science Translational Medicine · 2019 · 131 citations · 51 references
Life SciencesImmunologyPathologyAutoimmunityImmunopathologyInflammationAutoantibodiesAutoimmune Disease PathogenesisAutoimmune DiseasesAutoimmune Skin DiseasesSystemic Autoimmune DiseaseSystemic Lupus ErythematosusAutoimmune Skin PathologyCutaneous ImmunologyImmune Cell ExpansionPlasmacytoid Dendritic Cell ResponsesProgrammed Cell Death Protein 1 (Pd-1) PathwaySystemic Autoimmune Disease AssociationSystemic Lupus Erythematosus AssociationsSystemic Lupus Erythematosus Models
mice reduces cutaneous disease, autoantibodies, inflammatory cytokines, chemokines, and immune cell expansion. Furthermore, PD-1H on both T cells and myeloid cells including neutrophils and pDCs could transmit inhibitory signals, resulting in reduced activation and function, establishing PD-1H as an inhibitory receptor on T cells and myeloid cells. On the basis of these findings, we propose that PD-1H is a critical element in the pathogenesis and progression of lupus, and PD-1H activation could be effective for treatment of systemic and cutaneous lupus.
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