Concepedia

Chemical modification of the adeno-associated virus capsid to improve gene delivery

Mathieu Mével, Mohammed Bouzelha, Aurélien Leray, Simon Pacouret, Mickaël Guilbaud, Magalie Penaud‐Budloo, Dimitri Álvarez‐Dorta, Laurence Dubreil, Sébastien G. Gouin, Jean Philippe Combal,

Chemical Science · 2019 · 89 citations · 33 references

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Concepts

Abstract

Bioconjugated AAV vectors, achieved by coupling of ligands on amino groups of the capsid, are of great interest for gene delivery. Chemical modifications can be used to enhance cell tropism and to decrease interactions with neutralizing antibodies.

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