Chemical constituents and anti-inflammatory activity of essential oils of Datura stramonium L.

Abstract

The chemical constituents and anti-inflammatory activity of essential oils of Datura stramonium L. (family Solanaceae) are being reported. The essential oils were obtained by separate hydrodistillation of the air-dried and pulverized leaves and seeds of D. stramonium. The essential oils were analysed by means of gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). (72.5%) was identified as the main constituent of the leaf oil. However, citral (26.5%), 4,8-dimethyl-3,8-dien-2-one (11.2%), sesquirosefuran (11.1%) and geraniol (10.5%) were identified as the major constituents in the seed oil. The anti-inflammatory action was determined on fresh egg albumins over 4 h by measurement of baseline paw diameters. Oral administration of essential oils at a dose of 2% showed significant (p