Journal of Bacteriology · 2019 · 62 citations · 42 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceMedical MicrobiologyMicrobial PathogenesisBacterial BiofilmsBacterial PathogenesisBacterial Virulence FactorsBiofilm FormationMicrobial Virulence FactorsQuorum SensingAlginateAnti-biofilm StrategiesBacterial Biofilm ControlBacterial Biofilm-associated PathogenesisBiofilm DisruptionBiofilm-associated Virulence RegulationChronic Pseudomonas Aeruginosa InfectionPolymicrobial Interactions
CF patients are chronically infected by polymicrobial communities. The two dominant bacterial pathogens that infect the lungs of CF patients are P. aeruginosa and S. aureus , with ∼30% of patients coinfected by both species. Such coinfected individuals have worse outcomes than monoinfected patients, and both species persist within the same physical space. A variety of host and environmental factors have been demonstrated to promote P. aeruginosa - S. aureus coexistence, despite evidence that P. aeruginosa kills S. aureus when these organisms are cocultured in vitro . Thus, a better understanding of P. aeruginosa - S. aureus interactions, particularly mechanisms by which these microorganisms are able to coexist in proximal physical space, will lead to better-informed treatments for chronic polymicrobial infections.
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