Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease

Abstract

Both CD and UC patients have relative increases in the proportion of circulating Fla2-specific CD4⁺ T cells, which may be associated with changes in the intestinal microbiome. Evidence that the phenotype of these cells strongly correlate with disease severity provides insight into the potential roles of flagellin-specific CD4⁺ T cells in inflammatory bowel disease.